Scientists in a recent anti-aging breakthrough have discovered three hidden blood molecules originating from a blood-dwelling bacterium Paracoccus sanguinis ( P. sanguinis).
These naturally produced anti-aging compounds are rich with indole-functionized metabolites.
These indole-based metabolites are the by-products of Paracoccus sanguinis, known for their anti-inflammatory, anti-aging, and antimicrobial properties.
Given their broad-spectrum properties, Chung Sub Kim, Sullim Lee and their team developed the lab-grown culture of P. sanguinis and extracted indole metabolites from the culture.
According to Kim, "We became interested in P. sanguinis because blood-derived microbes are a relatively uncharted area of research.
“Given the unique environment of the bloodstream, we believed that studying individual species like P. sanguinis could reveal previously unknown metabolic functions relevant to health and disease,” he added.
According to findings published in the Journal of Natural Products, among 12 extracted indole metabolites tested for anti-aging purposes, three of them, including two newly identified ones, have shown efficacy in reducing the levels of cellular damage in human skin cells culture.
Moreover, these molecules also reduced the amounts of two proteins that are associated with inflammation and a protein that is involved in collagen damage.
These hidden blood molecules also lowered the levels of reactive oxygen species in these stressed skin cells when compared with untreated samples.
Based on these findings, the newly-identified indole molecules with anti-aging power could pave the way for future skin therapies.
