Scientists identify hidden brain nutrient drop as possible cause of anxiety

Researchers from UC Davis Health in a new study have discovered the potential cause of anxiety which is often fuelled by the decline in hidden brain nutrient levels.

The findings came from a meta-analysis of 25 previous studies which compared neuro-metabolites levels in 370 people with anxiety and 342 individuals without it.

The levels of chemicals were measured by the non-invasive MRI technique called proton magnetic resonance spectroscopy.

According to results, published in Molecular Psychiatry, the individuals grappling with anxiety issues tend to have 8 percent low amounts of choline in their brains compared to those without anxiety disorders.

The drop in choline was most clearly observed in the prefrontal cortex, a region which is involved in thinking, decision-making, and emotional regulation.

According to Jason Smucny, co-author of the study, “This is the first meta-analysis to show a chemical pattern in the brain in anxiety disorders. It suggests nutritional approaches -- like appropriate choline supplementation -- may help restore brain chemistry and improve outcomes for patients.”

The substantial amount of choline is important for memory, mood, cell membranes, and muscle control. It is produced in the body in a very small amount, thereby making dietary intake necessary.

According to researchers’ hypothesis, the possible cause of choline’s lower levels are associated with heightened flight-or-fight activity. As a result, it increases the brain’s demand for choline, causing a drop in available levels.

“We don't know yet if increasing choline in the diet will help reduce anxiety. More research will be needed,” Smucny added.

But a well-balanced nutrient nourishment will support both physical and mental health.