Four people working for the United Nations were killed on Friday during an attack on their camp in Aguelhok in northern Mali, the UN mission said.
The peacekeepers "bravely pushed back a complex attack carried out by several heavily-armed terrorists," MINUSMA said in a statement, adding that four troops had died and others were wounded according to a provisional toll.
The statement said the attackers had suffered heavy losses and had abandoned "several of their dead."
A source in MINUSMA said the attack occurred around 200 kilometres (120 miles) from the Algerian border, targeting a contingent of peacekeepers from Chad.
A Chadian military source said "two of our forces´ positions were attacked. We lost four people, including our forces´ detachment commander, and 16 were injured."
The UN force´s statement called the attack another "attempt against the peace process" that will "in no way undermine its determination to continue the execution of its mandate."
It thanked "international forces for their aerial support."
Also on Friday morning, two Malian soldiers were killed and around 10 wounded in an attack blamed on militants in Diafarabe in the country´s centre, Mali´s army said in a statement.
Local resident Youssouf Aya told AFP that he had seen a line of armed men on motorcycles headed toward a military post, they heard gunfire.
He said the assailants had "briefly occupied" the military post before leaving along the Niger River.
Mali has been struggling to contain an insurgency that first broke out in the north of the country in 2012 before spreading to the centre and neighbouring Burkina Faso and Niger.
Thousands have died and hundreds of thousands have fled their homes.
France, the former colonial power, intervened in Mali in 2013 to beat back the militants and now has some 5,100 soldiers deployed across the semi-arid Sahel region, though the mission has not been without controversy.
A UN probe published Tuesday concluded that a French airstrike in central Mali killed 19 civilians on January 3.
The French defence ministry has denied the account, insisting it had identified and attacked an "armed terrorist group".
On Friday, France´s military issued a statement on a separate incident, saying a woman died and a child was lightly wounded in a fire linked to an operation in Mali.
It said a suspected militant was also killed and two others captured in the operation overnight Wednesday to Thursday in an area southeast of Tessalit in the country´s north.
According to the statement, the soldiers were shot at by the suspected militant in a tent and returned fire.
The tent caught fire with the woman and child inside, it said. The child was evacuated to a military hospital with light wounds.