a 2007 semi-finalist and seeded 21, beat 11th seeded Grigor Dimitrov of Bulgaria for the fifth time in five meetings thanks to a 6-3, 6-4, 6-4 stroll.
Dimitrov had defeated 2013 champion Andy Murray on his way to the semi-finals last year, but Friday’s defeat extended a disappointing Grand Slam season for the 24-year-old who was beaten in the fourth round at the Australian Open before a first round exit at Roland Garros.
Fourth seed Stan Wawrinka reached the fourth round with a 6-4, 6-3, 6-4 victory over Fernando Verdasco for his first win over the Spaniard in 10 years.
The French Open champion will take on Belgium’s David Goffin for a place in the quarter-finals.
Goffin, the 16th seed, became only the fourth Belgian man to make the fourth round in the Open Era by defeating 2006 semi-finalist Marcos Baghdatis 6-3, 6-4, 6-2.
Friday’s programme began in sombre mood at the All England Club where thousands of fans joined officials and players in observing a minute’s silence for the victims of last week’s Tunisia beach massacre, most of whom were British.
Coco Vandeweghe, one of six American women in the third round, reached the last 16 at a Slam for the first time with a 6-2, 6-0 win over 2011 US Open champion Sam Stosur of Australia.
It was a second Grand Slam win of the season for world number 47 Vandeweghe against Stosur after also coming out on top at the Australian Open in January.
Stosur has yet to get beyond the third round at Wimbledon in 13 years of trying.
Vandeweghe will next face Czech sixth seed Lucie Safarova, who beat Sloane Stephens of the United States 3-6, 6-3, 6-1.
Teenager Belinda Bencic became the first Swiss woman into the fourth round since Patty Schnyder in 2007 when she defeated American qualifier Bethanie Mattek-Sands 7-5, 7-5.
Fresh from her first career title at Eastbourne last week, the 18-year-old 30th seed, revitalised after a medical time-out following the fifth game, came back from 5-1 down in the first set.
Former world number one and two-time semi-finalist Victoria Azarenka made the last 16 with a 6-4, 6-4 win over France’s Kristina Mladenovic and next faces Bencic.
Serena Williams continues her bid for a sixth Wimbledon and 21st major title by taking on Heather Watson, the last remaining British woman in the tournament.